This article focuses on a two treatment, two period, two treatment sequence crossover drug interaction study of a new drug and a standard oral contraceptive therapy. Both normal theory and distribution-free statistical analyses are provided along with a notable amount of graphical insight into the dataset. For one of the variables, the decision on the presence or absence of a drug interaction is reversed depending on whether the normal theory or the distribution-free analysis is favored. The data also contain statistically significant period effects, statistically significant but clinically unimportant treatment effects, some modest degree of structural nonnormality; and modest to more extreme outliers. This and 28 other pedagogically useful datasets can be found at www.math.iup.edu/~tshort/Bradstreet.
- Prof Dev