A two-year clinical research curriculum offered in a graduate program at a U.S. chiropractic college was implemented in Fall 2003 and enrolls three to six chiropractors per year. The curriculum includes ten credit hours of required courses in biostatistics. Introductory courses in biostatistical thinking and reasoning and data management are offered the first term, followed by basic statistical methods, statistical graphics, and advanced topics over the next three terms. Trainees typically have little previous exposure to statistics, so program objectives move from developing critical appraisal skills to writing strong data-related sections in grant applications. As graduates will likely pursue careers at chiropractic colleges with little or no research infrastructure, nor necessarily a research culture, it is paramount they develop a strong foundation in research methods and become proficient users of statistical tools to succeed.