Care must be taken in planning experiments so that the differences to be examined for significance should be those which furnish an answer to the question which we are asking. is a quote from British statistician William Sealy Gosset (a.k.a. Student: 1876 - 1937). The quote appears in a 1931 letter to "Biometrika" in which he was addressing some criticism of his work by Karl Pearson.
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