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== | == Researchers Fail to Reveal Full Drug Pay== | ||
New York Times June 8, 2008 <br> | |||
Gardner Harris and Benedict Carey | |||
<blockquote>A world-renowned Harvard child psychiatrist whose work has helped fuel an explosion in the use of powerful antipsychotic medicines in children earned at least $1.6 million in consulting fees from drug makers from 2000 to 2007 but for years did not report much of this income to university officials, according to information given Congressional investigators.<br><br> | |||
By failing to report income, the psychiatrist, Dr. Joseph Biederman, and a colleague in the psychiatry department at Harvard Medical School, Dr. Timothy E. Wilens, may have violated federal and university research rules designed to police potential conflicts of interest, according to Senator Charles E. Grassley, Republican of Iowa. Some of their research is financed by government grants.<br><br> | |||
Like Dr. Biederman, Dr. Wilens belatedly reported earning at least $1.6 million from 2000 to 2007, and another Harvard colleague, Dr. Thomas Spencer, reported earning at least $1 million after being pressed by Mr. Grassley’s investigators. But even these amended disclosures may understate the researchers’ outside income because some entries contradict payment information from drug makers, Mr. Grassley found.<br><br> | |||
In one example, Dr. Biederman reported no income from Johnson & Johnson for 2001 in a disclosure report filed with the university. When asked to check again, he said he received $3,500. But Johnson & Johnson told Mr. Grassley that it paid him $58,169 in 2001, Mr. Grassley found.<br><br> | |||
The Harvard group’s consulting arrangements with drug makers were already controversial because of the researchers’ advocacy of unapproved uses of psychiatric medicines in children. | |||
<\blockquote> | |||
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Revision as of 14:26, 3 July 2008
Quotations
A mathematician is a device for turning coffee into theorems.
Paul Erdős
Forsooth
Paul Alper suggested the following two Forsooths:
We want to persuade you of one claim: that William Sealy Gosset (1876-1937)--aka "Student" of Students t-test--was right and that his difficult friend, Ronald A. Fisher, though a genius, was wrong.
From the preface of Cult of Statistical Significance:
Deirdre Nansen McCloskey and Steve Ziliak
Feb 19, 2008
"There's this cluster of interrelated findings", said Richard A. Lippa, a professor of psychology at California State University at Fullerton, who has found evidence that in gay men, the hair on the back of the head is more likely to curl counterclockwise than in straight men. "These are all biological markers that something must have gone on early in development".
From an article by Rob Stein in the Washington Post,
February 5, 2008
Irreligion
Irreligion: A Mathematician Explains Why the Arguments for God Just Don't Add Up . By John Allen Paulos. 158 pp. Hill & Wang. $20.
John suggested that Chance News readers might enjoy some of the arguments that he used in his book that rely on probability concepts . We give a sample below and you can see more of his probability arguments in a talk he gave at the recent Conference "Beyond Belief Enlightenment 2.0" sponsored by the science network.
A common creationist argument goes roughly like the following. A very long sequence of individually improbable mutations must occur in order for a species or a biological process to evolve. If we assume these are independent events, then the probability of all of them occurring and occurring in the right order is the product of their respective probabilities, which is always a tiny number. Thus, for example, the probability of getting a 3, 2, 6, 2, and 5 when rolling a single die five times is 1/6 x 1/6 x 1/6 x 1/6 x 1/6 or 1/7,776 - one chance in 7,776. The much longer sequences of fortuitous events necessary for a new species or a new process to evolve leads to the minuscule probabilities that creationists argue prove that evolution is so wildly improbable as to be essentially impossible.
This line of argument, however, is deeply flawed. Leaving aside the issue of independent events, I note that there are always a fantastically huge number of evolutionary paths that might be taken by an organism (or a process), but there is only one that actually will be taken. So if, after the fact, we observe the particular evolutionary path actually taken and then calculate the a priori probability of its being taken, we will get the minuscule probability that creationists mistakenly attach to the process as a whole.
A related creationist argument is supplied Michael Behe, a key supporter of intelligent design. Behe likens what he terms the "irreducible complexity" of phenomena such as the clotting of blood to the irreducible complexity of a mousetrap. If just one of the trap's pieces is missing -- whether it be the spring, the metal platform, or the board -- the trap is useless. The implicit suggestion is that all the parts of a mousetrap would have had to come into being at once, an impossibility unless there were an intelligent designer. Design proponents argue that what's true for the mousetrap is all the more true for vastly more complex biological phenomena. If any of the 20 or so proteins involved in blood clotting is absent, for example, clotting doesn't occur, and so, the creationist argument goes, these proteins must have all been brought into being at once by a designer.
But the theory of evolution does explain the evolution of complex biological organisms and phenomena, and the Paley argument from design has been decisively refuted. Natural selection acting on the genetic variation created by random mutation and genetic drift results in those organisms with more adaptive traits differentially surviving and reproducing. (Interestingly, that we and all life have evolved from simpler forms by natural selection disturbs fundamentalists who are completely unphased by the Biblical claim that we come from dirt.) Further rehashing of defenses of Darwin or refutations of Paley is not my goal, however. Those who reject evolution are usually immune to such arguments anyway. Rather, my intention here is to develop some loose analogies between these biological issues and related economic ones and, secondarily, to show that these analogies point to a surprising crossing of political lines.
Paul Alper suggested that readers might enjoy the following:
Paulos often writes about unlikely events and how quickly the public tends to assume something supernatural is taking place. On page 52 of Irreligion he muses on numerological coincidences involving 9/11. He starts with 9/11 being "the telephone code for emergencies." The digits 9 + 1 + 1 sum to 11 and September 11 is the 254th day of the year so that 2 + 5 + 4 sum to 11. Further, there are another 111 days to the end of the year. The first plane to crash into the towers was flight number 11. The Pentagon, Afghanistan and New York City each have 11 letters. Moreover, any three-digit number when multiplied by 91 and 11 results in a six-digit number where digits four, five and six repeat digits one, two and three, respectively; in particular, starting with 911 results in 911,911. A few pages later he notes that on September 11, 2002 "the New York State lottery numbers were 911." The day before that,"the closing value of the September S&P 500 futures contracts" was 911. And to cinch it all, Johnny Unitas, the number one quarterback ever, died on September 11 and wore 19 on his jersey.
An improbable event and a coincidence
I have an example of an improbable event and a coincidence; it shows the difference between them. At Forrest's graduation last night, all of the seniors marched, in alphabetical order, to the stage to receive their diplomas. The women were wearing gray gowns and the men were wearing black gowns. I was careful to note any siblings (as far as I could tell, there were none). GREAT! So now we have a random sequence of coin tosses of length about 310, and the coin is pretty close to fair. The longest sequence of consecutive men I observed was 9; this is somewhat longer than the expected length of the longest run of heads, which is about 7, and somewhat longer than the expected length of the longest run of either heads or tails, which is about 8. So I observed a fairly unusual event. The coincidence is that Forrest was in the longest run of men.
An email from Charles Grinstead to Laurie Snell about his son's graduation.
The Drunkars's walk:How Randomness Rules Our Lives
Leonard Mlodinow
Pantheon Books, New York, 2008
There are not many writers who can successfully write about mathematics for the general public but Leonard Mlodinow is one of them. He is a physicist who has written a number of successful books on physics and mathematics for the general public. He has also been an editor for Star Treck.
The Drunkar's walk is his most recent book. In this book he shows that we all have a hard time understanding probability and yet it plays an important role in our daily lives. To show that we are not wired to understand probability, he has only to show us the birthday problem, the Monte Hall problem, the two sisters problems, the Linda problem the two-envelope problem etc.
Of course to understand how probability affects our lives we have to understand some basic probability. Mlodinow makes this more interesting by explaining probability along with the history of its development. He starts with Cardono introducing the sample space and solving dice problems. At the same time he discusses Cardono's colorful life. He then discusses Pascal and Fermat's solution to the problem of points. He continues with Bernoulli, deMere, and Bayes and explains their contributions including the law of large numbers, the central limit theory and conditional probability. Of course none of this is new but what makes this book so interesting is that while Mlodinow discusses probability concepts and applications he also explains how they can effect our lives. For example the argument that there is no such thing as a hot-hand in basketball might also be made about your stock advisor.
To hear this in action listen to Mlodinow himself here
You can also a review of this book and other similar books here by the well known probabilist David J. Aldus in the Berkeley Statistics Department. David teaches an Undergraduate Seminar From Undergraduate Probability Theory to the Real World. You will also find on his website a talk The top ten things that math probability says about the real world.
submitted by Laurie Snell
Researchers Fail to Reveal Full Drug Pay
New York Times June 8, 2008
Gardner Harris and Benedict Carey
A world-renowned Harvard child psychiatrist whose work has helped fuel an explosion in the use of powerful antipsychotic medicines in children earned at least $1.6 million in consulting fees from drug makers from 2000 to 2007 but for years did not report much of this income to university officials, according to information given Congressional investigators.
By failing to report income, the psychiatrist, Dr. Joseph Biederman, and a colleague in the psychiatry department at Harvard Medical School, Dr. Timothy E. Wilens, may have violated federal and university research rules designed to police potential conflicts of interest, according to Senator Charles E. Grassley, Republican of Iowa. Some of their research is financed by government grants.
Like Dr. Biederman, Dr. Wilens belatedly reported earning at least $1.6 million from 2000 to 2007, and another Harvard colleague, Dr. Thomas Spencer, reported earning at least $1 million after being pressed by Mr. Grassley’s investigators. But even these amended disclosures may understate the researchers’ outside income because some entries contradict payment information from drug makers, Mr. Grassley found.
In one example, Dr. Biederman reported no income from Johnson & Johnson for 2001 in a disclosure report filed with the university. When asked to check again, he said he received $3,500. But Johnson & Johnson told Mr. Grassley that it paid him $58,169 in 2001, Mr. Grassley found.
The Harvard group’s consulting arrangements with drug makers were already controversial because of the researchers’ advocacy of unapproved uses of psychiatric medicines in children. <\blockquote>
This was all discovered by